Progesterone utilizes the PI3K-AKT pathway in human spermatozoa to regulate motility and hyperactivation but not acrosome reaction
作者: Vrushali Sagare-PatilManvi VernekarMosami GalvankarDeepak Modi
作者单位: 1Molecular and Cellular Biology Laboratory, National Institute for Research in Reproductive Health, Indian Council of Medical Research, JM Street, Parel, Mumbai 400 012, India
刊名: Molecular and Cellular Endocrinology, 2013, Vol.374 (1-2), pp.82-91
来源数据库: Elsevier Journal
DOI: 10.1016/j.mce.2013.04.005
关键词: ProgesteroneSpermatozoaAKTMotilityAcrosome reactionCalcium
英文摘要: Abstract(#br)Progesterone is a physiologic regulator of sperm hyperactivation and acrosome reaction and it does so by activating a range of kinases present in the spermatozoa. In the present study, the involvement of the AKT- phosphatidylinositol 3-kinase (PI3K) signaling pathway in mediating progesterone response in human spermatozoa was investigated. In capacitated spermatozoa, progesterone transiently and concentration dependently lead to phosphorylation of AKT at both Thr 308 and Ser 473 in the tail region. This phosphorylation was inhibited by the PI3K inhibitor wortmannin, suggesting that progesterone leads to activation of PI3K-AKT pathway. The activation of AKT in response to progesterone is calcium dependent and the CatSper channel inhibitor mibefradil significantly reduced...
全文获取路径: Elsevier  (合作)
影响因子:4.039 (2012)

  • acrosome 顶体
  • spermatozoa 精子
  • reaction 反酌
  • pathway 轨道
  • motility 游动性
  • regulate 控制
  • human 人的