Aberrant expression of membranous carbonic anhydrase IX (CAIX) is associated with unfavorable disease course in papillary and clear cell renal cell carcinoma
作者: Franziska BüscheckChristoph FrauneRonald SimonMartina KluthClaudia Hube-MaggChristina Möller-KoopNavid ShadanpourClemens BannenbergChristian EichelbergDoris HöflmayerTill ClauditzCorinna WittmerWaldemar WilczakGuido SauterMargit FischMichael RinkTill Eichenauer
作者单位: 1Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
2Clinic for Urology, Krankenhaus St. Josef, Regensburg, Germany
3Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
刊名: Urologic Oncology: Seminars and Original Investigations, 2018
来源数据库: Elsevier Journal
DOI: 10.1016/j.urolonc.2018.08.015
关键词: Carbonic anhydrase IXRenal cancerPrognosis
原始语种摘要: Abstract(#br)Objective(#br)Antibodies against carbonic anhydrase IX (CAIX) are often part of immunohistochemical panels used to assist renal cell cancer (RCC) subtyping. This study was undertaken to determine, whether assessing CAIX expression levels could provide additional prognostic information.(#br)Methods and materials(#br)More than 1,800 RCCs were analyzed in a tissue microarray (TMA) format for CAIX expression. All tumors had been reviewed and newly classified according to the WHO 2016 classification.(#br)Results(#br)Membranous CAIX expression revealed a “black and white” pattern that was strikingly dependent on the RCC subtype. In clear cell RCC, 89.2% of cancers showed strong positivity. The few clear cell RCC with lower CAIX expression levels were more likely to exhibit...
全文获取路径: Elsevier  (合作)

  • expression 表示
  • anhydrase 脱水酶
  • papillary 乳头的
  • unfavorable 不利
  • clear 昧的
  • RCC Readiness Condition Coder
  • chromophobe 难染的
  • staining 染色
  • typically 典型地
  • detectable 可探测的