Malignant peripheral nerve sheath tumor: pathology and genetics
作者: Khin ThwayCyril Fisher
作者单位: 1Department of Histopathology, Sarcoma Unit, Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK
刊名: Annals of Diagnostic Pathology, 2014, Vol.18 (2), pp.109-116
来源数据库: Elsevier Journal
DOI: 10.1016/j.anndiagpath.2013.10.007
关键词: Malignant peripheral nerve sheath tumorNeurofibromatosis type 1NeurofibrosarcomaSarcomaTriton tumor
原始语种摘要: Abstract(#br)Malignant peripheral nerve sheath tumors are soft tissue neoplasms that show differentiation toward cells of the nerve sheath. They often arise from peripheral nerves or preexisting benign nerve sheath tumors and are generally high-grade neoplasms, which behave aggressively with high incidence of distant metastases. Malignant peripheral nerve sheath tumor can be histologically diverse and is difficult to diagnose because of its morphological overlap with a variety of other sarcomas and its lack of specific immunohistochemical markers or genetic profile. We review the pathology of malignant peripheral nerve sheath tumor, with reference to etiology, molecular genetics, and clinical factors.
全文获取路径: Elsevier  (合作)
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影响因子:0.975 (2012)

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关键词翻译
关键词翻译
  • peripheral 周边的
  • nerve 叶脉
  • sheath 
  • genetics 遗传学
  • pathology 病理学
  • tumor 肿胀
  • distant 远离的
  • neoplasms 新生物
  • arise 发生
  • benign 良性的