Piwi-like 1 and 4 gene transcript levels are associated with clinicopathological parameters in renal cell carcinomas
作者: Omar Al-JanabiSven WachElke NolteKatrin WeigeltTilman T. RauChristine StöhrWolfgang LegalStefan SchickThomas GreitherArndt HartmannBernd WullichHelge Taubert
作者单位: 1Department of Urology, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
2Institute of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
3Tumour Centre at the Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany
4Center for Reproductive Medicine and Andrology, Martin Luther University Halle-Wittenberg, Halle, Germany
刊名: BBA - Molecular Basis of Disease, 2014, Vol.1842 (5), pp.686-690
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbadis.2014.01.014
关键词: Piwi-like genesClear cell renal cell carcinomaQuantitative RT-PCRAgeNormal renal tissueTumorigenesis
原始语种摘要: Abstract(#br)Piwi-like gene family members (Piwil 1–4) are considered stem cell-associated genes/proteins. These are expressed predominantly in germline cells, but are re-expressed in different tumors. Piwil 1–4 gene expression has not previously been studied and correlated with clinicopathological parameters in renal cell carcinomas (RCC). The Piwil 1–4 transcript levels were analyzed by quantitative real-time PCR in 73 clear cell RCC (ccRCC) tissues and corresponding normal tissues. The transcript levels of Piwil 1, 2 and 4 were strongly and significantly correlated with each other, in both the tumor tissues and the normal tissues ( P <0.001; Spearman's rank test). Piwil 4 gene expression was significantly higher in the ccRCC tissues than that in...
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关键词翻译
关键词翻译
  • transcript 转录产物
  • renal 肾的
  • expression 表示
  • parameters 参数
  • member 
  • expressed 榨出的
  • divided 分部联箱
  • associated 相关的
  • higher 
  • family