Two new lignans from Gymnotheca chinensis Decne
作者: Shi-Ji XiaoYuan-Zhi LaoFang ChenHong-Xi XuLi-Sheng DingYan Zhou
作者单位: 1Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China
2College of Life Science, Sichuan University, Chengdu 610064, PR China
3Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China
刊名: Phytochemistry Letters, 2014, Vol.8 , pp.38-40
来源数据库: Elsevier Journal
DOI: 10.1016/j.phytol.2014.01.007
关键词: Gymnotheca chinensisSaururaceaeLignanCytotoxicity
原始语种摘要: Abstract(#br)Two new lignans, gymnothelignans V ( 1 ) and W ( 2 ), were isolated from a methanol extraction of Gymnotheca chinensis Decne. Their structures were established on the basis of extensive 1D and 2D NMR spectroscopy. Compound 1 exhibited moderate cytotoxicity against the HCT116, HCT15, A549, MCF-7 and HepG2 cancer cell lines with IC 50 values of 45.1μM, 26.9μM, 49.6μM, 30.0μM and 49.7μM, respectively. Compound 2 exhibited weak cytotoxicity against the A549 cancer cell line with an IC 50 value of 41.3μM.
全文获取路径: Elsevier  (合作)
影响因子:1.179 (2012)

  • lignans 木脂素类
  • values 价值观
  • cytotoxicity 细胞毒性
  • extensive 广泛的
  • moderate 适当的
  • established 确定
  • isolated 隔离
  • basis 
  • NMR N-Modular Redundancy
  • against 反对