Risk of Stroke in Patients With High On-Clopidogrel Platelet Reactivity to Adenosine Diphosphate After Percutaneous Coronary Intervention
作者: Nevio TaglieriMaria Letizia Bacchi ReggianiTullio PalmeriniGabriele GhettiFrancesco SaiaPamela GalloCarolina MorettiGianni Dall'AraCinzia MarrozziniAntonio MarzocchiClaudio Rapezzi
作者单位: 1Istituto di Cardiologia, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, Bologna, Italy
刊名: The American Journal of Cardiology, 2014, Vol.113 (11), pp.1807-1814
来源数据库: Elsevier Journal
DOI: 10.1016/j.amjcard.2014.03.009
英文摘要: Several prospective studies have shown that high on-clopidogrel platelet reactivity (HPR) in patients undergoing percutaneous coronary intervention (PCI) is a risk factor for ischemic events. All studies were insufficiently powered to detect differences in stroke between patients with HPR and those without. Therefore, we performed a systematic review and meta-analysis of available publications aimed at determining whether patients undergoing PCI with HPR are also at increased risk of stroke. We searched for prospective studies enrolling patients undergoing PCI and treated with aspirin and clopidogrel that reported on clinical relevance of HPR to adenosine diphosphate. Study end point was the rate of stroke. We also investigated whether there was an interaction on the relative risk of...
全文获取路径: Elsevier  (合作)
影响因子:3.209 (2012)