Post-translational modifications of the progesterone receptors
作者: Hany A. Abdel-HafizKathryn B. Horwitz
作者单位: 1Division of Endocrinology, Department of Medicine, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, USA
2Department of Pathology, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, USA
刊名: Journal of Steroid Biochemistry and Molecular Biology, 2014, Vol.140 , pp.80-89
来源数据库: Elsevier Journal
DOI: 10.1016/j.jsbmb.2013.12.008
关键词: Progesterone receptorPost-translational modificationSUMOylationPhosphorylationTranscriptional activityBreast cancer
原始语种摘要: Abstract(#br)Progesterone plays a key role in the development, differentiation and maintenance of female reproductive tissues and has multiple non-reproductive neural functions. Depending on the cell and tissue, the hormonal environment, growth conditions and the developmental stage, progesterone can either stimulate cell growth or inhibit it while promoting differentiation. Progesterone receptors (PRs) belong to the steroid hormone receptor superfamily of ligand-dependent transcription factors. PR proteins are subject to extensive post-translational modifications that include phosphorylation, acetylation, ubiquitination and SUMOylation. The interplay among these modifications is complex with alteration of the receptors by one factor influencing the impact of another. Control over these...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • translational 平移的
  • developmental 试验性的
  • protein 蛋白质
  • progesterone 孕酮
  • extensive 广泛的
  • specific 
  • tissue 组织
  • alteration 蚀变
  • activity 活度
  • superfamily 总科