The role of nicotinic receptors in shaping and functioning of the glutamatergic system: A window into cognitive pathology
作者: Susanna MolasMara Dierssen
作者单位: 1Systems Biology Program, Centre for Genomic Regulation (CRG), Barcelona E-08003, Spain
2University Pompeu Fabra (UPF), Spain
3CIBER de Enfermedades Raras (CIBERER), Barcelona E-08003, Spain
刊名: Neuroscience and Biobehavioral Reviews, 2014, Vol.46 , pp.315-325
来源数据库: Elsevier Journal
DOI: 10.1016/j.neubiorev.2014.05.012
关键词: Nicotinic receptorsnAChRsNeuronal plasticityIntellectual disability
原始语种摘要: Abstract(#br)The involvement of the cholinergic system in learning, memory and attention has long been recognized, although its neurobiological mechanisms are not fully understood. Recent evidence identifies the endogenous cholinergic signaling via nicotinic acetylcholine receptors (nAChRs) as key players in determining the morphological and functional maturation of the glutamatergic system. Here, we review the available experimental and clinical evidence of nAChRs contribution to the establishment of the glutamatergic system, and therefore to cognitive function. We provide some clues of the putative underlying molecular mechanisms and discuss recent human studies that associate genetic variability of the genes encoding nAChR subunits with cognitive disorders. Finally, we discuss the new...
全文获取路径: Elsevier  (合作)
影响因子:9.44 (2012)

  • cognitive 修]认知[识
  • system 
  • establishment 确立
  • functional 功能的
  • available 可供应的
  • although 虽然
  • nicotinic 烟碱酸的
  • genetic 遗传的
  • cholinergic 胆碱能的
  • fully 充分