Primary cutaneous follicle center lymphoma with diffuse CD30 expression: A report of 4 cases of a rare variant
作者: Werner KempfDmitry V. KazakovArno RüttenRudolf A. RupecPetr TalarcikVeronika BallováKatrin KerlReinhard DummerStephan LautenschlagerDieter R. ZimmermannMarianne Tinguely
作者单位: 1Kempf und Pfaltz, Histologische Diagnostik, Zurich, Switzerland
2Department of Dermatology, University Hospital, Zurich, Switzerland
3Department of Pathology, Medical Faculty in Pilsen, Charles University, Prague, Czech Republic
4Dermatopathologie Friedrichshafen, Friedrichshafen, Germany
5Derma AG, Solothurn, Switzerland
6Department of Dermatology, Ludwig-Maximilians-University, Munich, Germany
7Cytopathos Laboratories, Bratislava, Slovak Republic
8National Oncology Department, Bratislava, Slovak Republic
9Dermatologisches Ambulatorium, Stadtspital Triemli, Zurich, Switzerland
10Molecular Biology Laboratory, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
刊名: Journal of the American Academy of Dermatology, 2014, Vol.71 (3), pp.548-554
来源数据库: Elsevier Journal
DOI: 10.1016/j.jaad.2014.03.027
关键词: CD30cutaneous lymphomadiffuse large B-cell lymphomafollicular lymphomaGorlin–Goltz syndromePTCH
英文摘要: Background(#br)CD30 is expressed in aggressive and Epstein–Barr virus–associated forms of B-cell non-Hodgkin lymphomas, but is rarely expressed by the majority of tumor cells in primary cutaneous B-cell lymphomas (CBCLs). The expression of CD30 in CBCLs may be at risk for misinterpretation as an unequivocal indicator of a highly aggressive form of the disease.(#br)Objective(#br)We report 4 cases of low malignant primary cutaneous follicle center lymphoma (PCFCL) with diffuse and strong expression of CD30 by the majority of neoplastic cells.(#br)Results(#br)The patients included 3 men and 1 woman with tumors on the scalp (3 patients) and chest wall (1 patient). The histologic examinations revealed a mixed, diffuse, and follicular growth pattern with CD20 + , bcl-6 + , and bcl-2 − tumor...
全文获取路径: Elsevier  (合作)

  • lymphoma 淋巴瘤
  • follicle 滤泡
  • diffuse 普及
  • variant 变体
  • cutaneous 皮肤的
  • expression 表示
  • center 中心
  • report 通报