Dominance of chemokine ligand 2 and matrix metalloproteinase-2 and -9 and suppression of pro-inflammatory cytokines in the epidural compartment after intervertebral disc extrusion in a canine model
作者: Philemon KarliValentine MartléKenny BossensArtur SummerfieldMarcus G. DoherrPaul TurnerMarc VandeveldeFranck ForterreDiana Henke
作者单位: 1Division of Neurological Sciences, Department of Clinical Veterinary Neurology, Vetsuisse Faculty, University of Bern, Länggassstrasse 128, Bern CH-3001, Switzerland
2Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
3Research Department, Institute of Virology and Immunoprophylaxis (IVI), Sensemattstrasse 293, 3147 Mittelhäusern, Switzerland
4Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, Länggassstrasse 128, Bern CH-3001, Switzerland
5Affymetrix UK Ltd, Voyager, Mercury Park, Wycombe Lane, Wooburn Green, High Wycombe HP10 0HH, UK
6Division of Clinical Surgery, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Länggassstrasse 128, Bern CH-3001, Switzerland
刊名: The Spine Journal, 2014, Vol.14 (12), pp.2976-2984
来源数据库: Elsevier Journal
DOI: 10.1016/j.spinee.2014.05.021
关键词: Epidural spaceMicroarrayIL-8MCP-1CCL2MMP
原始语种摘要: Abstract(#br)Background context(#br)In canine intervertebral disc (IVD) disease, a useful animal model, only little is known about the inflammatory response in the epidural space.(#br)Purpose(#br)To determine messenger RNA (mRNA) expressions of selected cytokines, chemokines, and matrix metalloproteinases (MMPs) qualitatively and semiquantitatively over the course of the disease and to correlate results to neurologic status and outcome.(#br)Study design/setting(#br)Prospective study using extruded IVD material of dogs with thoracolumbar IVD extrusion.(#br)Patient sample(#br)Seventy affected and 13 control (24 samples) dogs.(#br)Outcome measures(#br)Duration of neurologic signs, pretreatment, neurologic grade, severity of pain, and outcome were recorded. After diagnostic imaging,...
全文获取路径: Elsevier  (合作)
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影响因子:3.355 (2012)

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关键词翻译
关键词翻译
  • epidural 硬膜外的
  • intervertebral 椎间的
  • compartment 隔间
  • cytokines 细胞浆移动
  • inflammatory 激怒的
  • ligand 配合体
  • suppression 抑制
  • canine 大齿
  • matrix 石基
  • after 在之后