Characterization of peptide QRFP (26RFa) and its receptor from amphioxus, Branchiostoma floridae
作者: Bo XuChristina A. BergqvistGörel SundströmIngrid LundellHubert VaudryJérôme LeprinceDan Larhammar
作者单位: 1Department of Neuroscience, Science for Life Laboratory, Uppsala University, Box 593, SE-75124 Uppsala, Sweden
2INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine (IRIB), Regional Platform for Cell Imaging of Haute-Normandie (PRIMACEN), University of Rouen, 76821 Mont-Saint-Aignan, France
刊名: General and Comparative Endocrinology, 2015, Vol.210 , pp.107-113
来源数据库: Elsevier Journal
DOI: 10.1016/j.ygcen.2014.10.010
关键词: AmphioxusLanceletNeuropeptideG protein-coupled receptorEvolution
英文摘要: Abstract(#br)A peptide ending with RFamide (Arg-Phe-amide) was discovered independently by three different laboratories in 2003 and named 26RFa or QRFP. In mammals, a longer version of the peptide, 43 amino acids, was identified and found to bind to the orphan G protein-coupled receptor GPR103. We searched the genome database of Branchiostoma floridae (Bfl) for receptor sequences related to those that bind peptides ending with RFa or RYa (including receptors for NPFF, PRLH, GnIH, and NPY). One receptor clustered in phylogenetic analyses with mammalian QRFP receptors. The gene has 3 introns in Bfl and 5 in human, but all intron positions differ, implying that the introns were inserted independently. A QRFP-like peptide consisting of 25 amino acids and ending with RFa was identified in the...
全文获取路径: Elsevier  (合作)
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影响因子:2.823 (2012)

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关键词翻译
关键词翻译
  • amphioxus 文昌鱼属
  • receptor 接受体
  • coupled 耦合
  • protein 蛋白质