SIN1, a critical component of the mTOR-Rictor complex, is overexpressed and associated with AKT activation in medullary and aggressive papillary thyroid carcinomas
作者: Dimitrios MoraitisMaria KaranikouChryssa LiakouKonstantinos DimasGeorge TzimasSofia Tseleni-BalafoutaEfstratios PatsourisGeorge Z. RassidakisMaria A. Kouvaraki
作者单位: 1Department of Surgery, Hygeia Hospital, Athens, Greece
2First Department of Pathology, National and Kapodistrian University of Athens School of Medicine, Athens, Greece
3Department of Pharmacology, University of Thessaly, Larissa, Greece
4Department of Pathology, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden
5Department of Endocrine Surgery, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden
刊名: Surgery, 2014, Vol.156 (6), pp.1542-1549
来源数据库: Elsevier Journal
DOI: 10.1016/j.surg.2014.08.095
原始语种摘要: Background(#br)Mammalian target of rapamycin (mTOR) forms 2 active complexes in the cell: the rapamycin-sensitive mTOR-Raptor (mTORC1) and the rapamycin-insensitive mTOR-Rictor (mTORC2). The latter activates AKT kinase, which promotes tumor cell survival and proliferation by multiple downstream targets. Mammalian stress-activated protein kinase interacting protein 1 (SIN1), an essential subunit of the mTORC2 complex, maintains the integrity of the complex and substrate specificity and regulates Akt activation. The role of mTOR-Rictor complex activation in thyroid carcinogenesis remains unknown. Therefore, we investigated expression patterns of Sin1 in the cells lines of thyroid carcinoma and tumors and their association with AKT activation, histologic type, and tumor...
全文获取路径: Elsevier  (合作)
影响因子:3.373 (2012)

  • papillary 乳头的
  • aggressive 侵蚀的
  • medullary 脊髓的
  • thyroid 甲状腺
  • component 成分
  • associated 相关的
  • complex 超群
  • critical 临界的
  • activation 活化