MRP1 and GSTp1 expression in non-small cell lung cancer does not correlate with clinicopathological parameters: A Slovakian population study
作者: Silvia RybárováIngrid HodorováJozef MihalikLadislav Mirossay
作者单位: 1Department of Anatomy, Faculty of Medicine, P.J. Šafárik University, Šrobárova 2, 041 80 Košice, Slovak Republic
2Department of Pharmacology, Faculty of Medicine, P.J. Šafárik University, tr. SNP 1, 040 11 Košice, Slovak Republic
刊名: Acta Histochemica, 2014, Vol.116 (8), pp.1390-1398
来源数据库: Elsevier Journal
DOI: 10.1016/j.acthis.2014.09.002
关键词: Lung cancerMRP1Glutathione-S-transferase p1Immunohistochemistry
原始语种摘要: Abstract(#br)We detected MRP1 (multidrug resistance-associated protein 1) and GSTp1 (glutathione-S-transferase p1) protein expression in samples of non-small cell lung cancer (NSCLC) and our results were compared to basic clinicopathological parameters. The indirect immunohistochemical method was used for localization of monitored proteins. A total of 135 tissue samples of NSCLC were characterized according to histopathological type of tumor. Next, we compared our results with basic clinicopathological parameters (histopathological type of tumor, tumor grade and TNM stage of disease). In MRP1 and GSTp1 positive tumor cells, strong brown cytoplasmic immunostaining was visible. In our set of samples 71% showed MRP1 positivity, while according to histopathological type the squamous cell...
全文获取路径: Elsevier  (合作)
影响因子:1.608 (2012)

  • proteins 蛋白质
  • adenocarcinoma 腺癌
  • expression 表示
  • cancer 癌症
  • parameters 参数
  • statistically 统计地
  • transferase 转移酵素
  • correlation 对比
  • grade 品位
  • squamous 具鳞的