Pro-oxidative, genotoxic and cytotoxic properties of uranyl ions
作者: S.A. GarmashV.S. SmirnovaO.E. KarpA.M. UsachevaA.V. BerezhnovV.E. IvanovA.V. ChernikovV.I. BruskovS.V. Gudkov
作者单位: 1Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia
2Pushchino State University, Pushchino, Moscow Region 142290, Russia
3Institute of Cell Biophysics, Russian Academy of Sciences, 3 Institutskaya Street, Pushchino, Moscow Region 142290, Russia
刊名: Journal of Environmental Radioactivity, 2014, Vol.127 , pp.163-170
来源数据库: Elsevier Journal
DOI: 10.1016/j.jenvrad.2012.12.009
关键词: Uranyl ionsReactive oxygen speciesLong-lived protein radicals8-oxoguanine
英文摘要: Abstract(#br)It is demonstrated that hydroxyl radicals and hydrogen peroxide are formed under the action of uranyl ions in aqueous solutions containing no reducing agents. In the presence of uranyl ions, formation of 8-oxoguanine in DNA and long-lived protein radicals are observed in vitro . It is shown that the pro-oxidant properties of uranyl at micromolar concentrations mostly result from the physico-chemical nature of the compound rather than its radioactive decay. Uranyl ions lead to damage in DNA and proteins causing death of HEp-2 cells by necrotic pathway. It is revealed that the uranyl ions enhance radiation-induced oxidative stress and significantly increase a death rate of mice exposed to sublethal doses of X-rays.
全文获取路径: Elsevier  (合作)
影响因子:2.119 (2012)

  • cytotoxic 细胞毒素的
  • uranyl 铀酰
  • properties 道具