Arsenic trioxide induces programmed cell death through stimulation of ER stress and inhibition of the ubiquitin–proteasome system in human sarcoma cells
作者: Hui-Wen ChiuYin-Chiu TsengYung-Ho HsuYuh-Feng LinNing-Ping FooHow-Ran GuoYing-Jan Wang
作者单位: 1Department of Environmental and Occupational Health, National Cheng Kung University, Tainan, Taiwan
2Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taiwan
3Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan
4Department of Emergency Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan
5Department of Emergency Medicine, China Medical University-An Nan Hospital, Tainan, Taiwan
6Department of Occupational and Environmental Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
7Department of Biomedical Informatics, Asia University, Taichung, Taiwan
8Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan
刊名: Cancer Letters, 2015, Vol.356 (2), pp.762-772
来源数据库: Elsevier Journal
DOI: 10.1016/j.canlet.2014.10.025
关键词: SarcomaArsenic trioxideUbiquitin–proteasome systemEndoplasmic reticulum stressAutophagyApoptosis
原始语种摘要: Abstract(#br)Sarcoma is a rare form of cancer that differs from the much more common carcinomas because it occurs in a distinct type of tissue. Many patients of sarcoma have poor response to chemotherapy and an increased risk for local recurrence. Arsenic trioxide (ATO) is used to treat certain types of leukemia. Recently, data have revealed that ATO induces sarcoma cell death in several types of solid tumor cell lines. In the present study, we investigated whether ATO induces cancer cell death and elucidated the underlying anti-cancer mechanisms. Our results showed that ATO caused concentration- and time-dependent cell death in human osteosarcoma and fibrosarcoma cells. The types of cell death that were induced by ATO were primarily autophagy and apoptosis. Furthermore, ATO activated...
全文获取路径: Elsevier  (合作)
影响因子:4.258 (2012)

  • sarcoma 肉瘤
  • trioxide 三氧化物
  • treat 处理
  • combined 组合
  • stress 应力
  • death 
  • stimulation 激励
  • ubiquitin 泛激素
  • inhibition 抑制
  • antitumor 抗癌的