Radiation Therapy Overcomes Adverse Prognostic Role of Cyclooxygenase-2 Expression on Reed-Sternberg Cells in Early Hodgkin Lymphoma
作者: Francisco MestreAntonio GutiérrezJose RodriguezRafael RamosJuan Fernando GarciaJordi Martinez-SerraMarta CasasusCristina NicolauLeyre BentoInes HerraezPaloma Lopez-PerezaguaJaime DaumalJoan Besalduch
作者单位: 1Service of Radiation Therapy, University Hospital Son Espases, Instituto de Investigación Sanitaria de Palma, Palma de Mallorca, Spain
2Service of Hematology, University Hospital Son Espases, Instituto de Investigación Sanitaria de Palma, Palma de Mallorca, Spain
3Service of Pathology, University Hospital Son Espases, Instituto de Investigación Sanitaria de Palma, Palma de Mallorca, Spain
4MD Anderson Cancer Center, Madrid, Spain
5Spanish National Cancer Research Centre, Madrid, Spain
6Service of Radiation Therapy, Policlinica Miramar, Palma de Mallorca, Spain
7Service of Radiology, IDISPA, Palma de Mallorca, Spain
8Service of Nuclear Medicine, IDISPA, Palma de Mallorca, Spain
刊名: International Journal of Radiation Oncology, Biology, Physics, 2015, Vol.92 (1), pp.84-90
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijrobp.2014.10.004
英文摘要: Purpose(#br)To analyze the role of radiation therapy (RT) on the adverse prognostic influence of cyclooxygenase-2 (COX-2) expression on Reed-Sternberg (RS) cells, in the setting of early Hodgkin lymphoma (HL) treated with ABVD (adriamycin, vinblastine, bleomycin, dacarbazine).(#br)Methods and Materials(#br)In the present study we retrospectively investigated the prognostic value of COX-2 expression in a large (n=143), uniformly treated early HL population from the Spanish Network of HL using tissue microarrays. Univariate and multivariate analyses were done, including the most recognized clinical variables and the potential role of administration of adjuvant RT.(#br)Results(#br)Median age was 31 years; the expression of COX-2 defined a subgroup with significantly worse prognosis....
全文获取路径: Elsevier  (合作)
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