Umbilical cord blood mesenchymal stem cells co-modified by TERT and BDNF: A novel neuroprotective therapy for neonatal hypoxic-ischemic brain damage
作者: Fengyan ZhaoYi QuHaiting LiuBaowen DuDezhi Mu
作者单位: 1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
2Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu 610041, China
3Department of Pediatrics and Neurology, University of California, San Francisco, CA 94143, USA
4Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
刊名: International Journal of Developmental Neuroscience, 2014, Vol.38 , pp.147-154
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijdevneu.2014.06.014
关键词: Telomerase reverse transcriptaseBrain-derived neurotrophic factorHypoxic-ischemic brain damageUmbilical cord blood mesenchymal stem cells
原始语种摘要: Abstract(#br)Hypoxic-ischemic brain damage (HIBD), a leading cause of perinatal disability and death, has limited therapeutic options. Stem cell therapy has been demonstrated as a potential novel therapy for neurological disorders. Compared with other types of stem cells, umbilical cord blood mesenchymal stem cells (UCB-MSCs) have several unique characteristics, such as a higher rate of cell proliferation and clonality. However, the limited life span of UCB-MSCs hinders their clinical application. Therefore, efforts are urgently needed to circumvent this disadvantage. Telomerase reverse transcriptase (TERT), which promotes cell proliferation and survival, plays a protective role in hypoxic-ischemic (HI) brain injury. Thus, it is reasonable to propose that UCB-MSCs modified by exogenous...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • novel 长篇小说
  • transcriptase 转录酶
  • mesenchymal 间叶细胞的
  • hypoxic 含氧量低的
  • brain 
  • ischemic 福尔克曼氏麻痹
  • blood 血液
  • demonstrated 探明的储量
  • maintain 
  • neurotrophic 神经营养的