Novel type of VanB 2 teicoplanin-resistant hospital-associated Enterococcus faecium
作者: Antonella SantonaBianca PagliettiAhmed A. Al-QahtaniMarie Fe F. BoholAbiola SenokMassimo DeligiosSalvatore RubinoMohammed N. Al-Ahdal
作者单位: 1Dipartimento di Scienze Biomediche, Università di Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy
2Department of Infection and Immunity, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354 (MBC-03), Riyadh 11211, Saudi Arabia
3Liver Disease Research Centre, King Saud University, Riyadh, Saudi Arabia
4College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
刊名: International Journal of Antimicrobial Agents, 2014, Vol.44 (2), pp.156-159
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijantimicag.2014.05.005
关键词: MLSTHospital-associatedEnterococcus faeciumTeicoplanin resistance mechanism
原始语种摘要: Abstract(#br)Seven high-risk clones of vancomycin-resistant Enterococcus faecium (VREF) belonging to clonal complex 17 were identified using multilocus sequence typing (MLST) among clinical isolates from Saudi Arabia. Among these isolates, a new hospital-associated sequence type (ST795), VanB 2 -type teicoplanin-resistant strain was detected. Its unusual phenotype resulted from a new combination of mutations in the ddl , vanS and vanW genes, which confirmed the trend of evolution in VanB-type resistance. Furthermore, characteristics of adaptation and persistence in the hospital environment of ST795 were emphasised by the presence of genes and clusters recognised to be specific for hospital-associated VREF.
全文获取路径: Elsevier  (合作)
影响因子:4.415 (2012)

  • hospital 医院
  • resistant 耐久的
  • associated 相关的
  • vancomycin 万古霉素
  • isolates 单离体
  • persistence 余辉时间
  • confirmed 已确认的
  • sequence 次序
  • complex 超群
  • detected 找到