MALDI imaging–based identification of prognostically relevant signals in bladder cancer using large-scale tissue microarrays 1 These authors contributed equally to this work.
作者: Stefan SteurerJulius Magnus SingerMichael RinkFelix ChunRoland DahlemRonald SimonEike BurandtPhillip StahlLuigi TerraccianoThorsten SchlommWalter WagnerWolfgang HöppnerMaryam OmidiOlga KrausMarcel KwiatkowskiOusman DohMargit FischArmin SoaveGuido SauterMarcus WurlitzerHartmut SchlüterSarah Minner
作者单位: 1Department of Pathology at the University Medical Center Hamburg-Eppendorf, Hamburg, Germany
2Department of Urology at the University Medical Center Hamburg-Eppendorf, Hamburg, Germany
3Department of Pathology, Cantonal Hospital Basel, Basel, Switzerland
4Martini Clinic at the University Medical Center Hamburg-Eppendorf, Hamburg, Germany
5Department of Urology, Federal Armed Forces Hospital, Hamburg, Germany
6Department of Urology and Pediatric Urology, Medical Center Itzehoe, Itzehoe, Germany
7Department of Clinical Chemistry at the University Medical Center Hamburg-Eppendorf, Hamburg, Germany
8Department of Urology, Regio Clinic Wedel, Wedel, Germany
刊名: Urologic Oncology: Seminars and Original Investigations, 2014, Vol.32 (8), pp.1225-1233
来源数据库: Elsevier Journal
DOI: 10.1016/j.urolonc.2014.06.007
关键词: MALDI mass spectrometry imagingTissue microarrayBladder cancerTMA
原始语种摘要: Abstract(#br)Objective(#br)Although most patients with urinary bladder cancer present with noninvasive and low-malignant stages of the disease, about 20% eventually develop life-threatening metastatic tumors. This study was designed to evaluate the potential of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) to identify molecular markers predicting the clinical course of bladder cancer.(#br)Materials and methods(#br)We employed MALDI-MSI to a bladder cancer tissue microarray including paraffin-embedded tissue samples from 697 patients with clinical follow-up data to search for prognostically relevant associations.(#br)Results(#br)Analysis of our MALDI imaging data revealed 40 signals in the mass spectra ( m/z signals) associated with epithelial...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • bladder 膀胱
  • cancer 癌症
  • tissue 组织
  • urinary 尿的
  • relevant 有关联的
  • stage 
  • nodal 部件的
  • large 大的
  • clinically 临床上
  • survival 生存