Facile and diastereoselective synthesis of 3,2′-spiropyrrolidine-oxindoles derivatives, their molecular docking and antiproliferative activities
作者: D. KathirvelanJ. HaribabuB.S.R. ReddyC. BalachandranV. Duraipandiyan
作者单位: 1Industrial Chemistry Laboratory, CSIR-Central Leather Research Institute, Adyar, Chennai 600 020, India
2Division of Microbiology and Cancer Biology, Entomology Research Institute, Loyola College, Chennai 600034, India
刊名: Bioorganic & Medicinal Chemistry Letters, 2015, Vol.25 (2), pp.389-399
来源数据库: Elsevier Journal
DOI: 10.1016/j.bmcl.2014.10.099
关键词: Multicomponent reactionSpirooxindolePyrazole moietyAntimicrobial activityMolecular docking
英文摘要: Abstract(#br)In the present study, a series of novel highly functionalized spiropyrrolidine–oxindoles have been synthesized through 1,3-dipolar cycloaddition of an azomethine ylide formed from isatin and various amino acids such as sarcosine, proline and thioproline with the dipolarophile ( E )-3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile under optimized conditions. All the synthesized compounds were evaluated for their antimicrobial activity and shown significant activity.
全文获取路径: Elsevier  (合作)
影响因子:2.338 (2012)

  • docking 靠泊
  • reaction 反酌
  • moiety 一部分
  • synthesis 合成
  • activity 活度
  • derivatives 派生物
  • their 他们的
  • molecular 分子的