Quinone compounds regulate the level of ROS production by the NADPH oxidase Nox4
作者: Minh Vu Chuong NguyenBernard LardyFrancis RoussetFlorence Hazane-PuchLeilei ZhangCandice TrocméLena SerranderKarl-Heinz KrauseFrançoise Morel
作者单位: 1Université Joseph Fourier, GREPI AGIM FRE 3405, CNRS, EPHE, Grenoble, France
2Department of Clinical Microbiology, University Hospital, Linkoping, Sweden
3Department of Pathology and Immunology, Medical Faculty and University Hospital, Geneva, Switzerland
4Laboratoire de Biochimie Enzyme et Protéine-DBTP, Institut de Biologie et de Pathologie, University Hospital CHU-Grenoble, Grenoble, France
5Laboratoire de Biochimie Hormonale et Nutritionnelle-DBTP, Institut de Biologie et de Pathologie, University Hospital CHU-Grenoble, Grenoble, France
刊名: Biochemical Pharmacology, 2013, Vol.85 (11), pp.1644-1654
来源数据库: Elsevier Journal
DOI: 10.1016/j.bcp.2013.03.023
关键词: NADPH oxidase Nox4NAD(P)H:quinone oxidoreductase NQO1QuinonesRedox regulation of NoxReactive oxygen species (ROS)
原始语种摘要: Abstract(#br)NADPH oxidase Nox4 is expressed in a wide range of tissues and plays a role in cellular signaling by providing reactive oxygen species (ROS) as intracellular messengers. Nox4 oxidase activity is thought to be constitutive and regulated at the transcriptional level; however, we challenge this point of view and suggest that specific quinone derivatives could modulate this activity. In fact, we demonstrated a significant stimulation of Nox4 activity by 4 quinone derivatives (AA-861, t BuBHQ, t BuBQ, and duroquinone) observed in 3 different cellular models, HEK293E, T-REx™, and chondrocyte cell lines. Our results indicate that the effect is specific toward Nox4 versus Nox2. Furthermore, we showed that NAD(P)H:quinone oxidoreductase (NQO1) may participate in this stimulation....
全文获取路径: Elsevier  (合作)
影响因子:4.576 (2012)

  • oxidoreductase 氧化还原酶
  • regulate 控制
  • NADPH 还原型烟酰胺腺嘌呤二核苷酸磷酸
  • oxidase 氧化酶
  • quinone 
  • demonstrated 探明的储量
  • activity 活度
  • observed 观察到的
  • disulfide 二硫化物
  • regulation