In vitro anticancer activity of methyl caffeate isolated from Solanum torvum Swartz. fruit
作者: C. BalachandranN. EmiY. ArunY. YamamotoB. AhilanB. SangeethaV. DuraipandiyanYoko InagumaAkinao OkamotoS. IgnacimuthuN.A. Al-DhabiP.T. Perumal
作者单位: 1Department of Hematology, Fujita Health University, 1-98, Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan
2Organic & Bio-organic Chemistry Laboratory, CSIR-Central Leather Research Institute, Chennai 600 020, India
3Department of Toxicology, Advinus Therapeutics Ltd, Bangalore 560058, India
4Department of Botany and Microbiology, Addiriya Chair for Environmental Studies, College of Science, King Saud University, P.O.Box.2455, Riyadh 11451, Saudi Arabia
5Division of Cancer Biology, Entomology Research Institute, Loyola College, Chennai 600 034, India
刊名: Chemico-Biological Interactions, 2015, Vol.242 , pp.81-90
来源数据库: Elsevier Journal
DOI: 10.1016/j.cbi.2015.09.023
关键词: Solanum torvumCaspasesCytochrome cp53Molecular docking
英文摘要: Abstract(#br)The present study was undertaken to investigate the anticancer activity of methyl caffeate isolated from Solanum torvum Swartz. fruit and to explore the molecular mechanisms of action in MCF-7 cells. Cytotoxic properties of hexane, ethyl acetate and methanol extracts were carried out against MCF-7 cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Ethyl acetate extract showed good cytototoxic activities compared to hexane and methanol extracts. Methyl caffeate was isolated from the ethyl acetate extract using column chromatography. Cytotoxic properties of methyl caffeate was investigated against MCF-7, A549, COLO320, HepG-2 and Vero cells. The compound showed potent cytotoxic properties against MCF-7 cells compared to A549, COLO320 and HepG-2...
全文获取路径: Elsevier  (合作)
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影响因子:2.967 (2012)

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关键词翻译
关键词翻译
  • fruit 水果
  • anticancer 抗癌的
  • Solanum 茄属
  • methyl 甲基
  • isolated 隔离
  • activity 活度
  • vitro 体外