Insulin-like growth factor binding protein-3 (IGFBP-3) plays a role in the anti-tumorigenic effects of 5-Aza-2′-deoxycytidine (AZA) in breast cancer cells
作者: Li ZengCaroline JarrettKeith BrownKathleen M. GillespieJeff M.P. HollyClaire M. Perks
作者单位: 1IGFs & Metabolic Endocrinology Group, University of Bristol, Learning & Research Building, Southmead Hospital, Bristol BS10 5NB, United Kingdom
2School of Cellular & Molecular Medicine, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
3Diabetes and Metabolism, School of Clinical Sciences, University of Bristol, Learning & Research Building, Southmead Hospital, Bristol BS10 5NB, United Kingdom
刊名: Experimental Cell Research, 2013, Vol.319 (14), pp.2282-2295
来源数据库: Elsevier Journal
DOI: 10.1016/j.yexcr.2013.06.011
关键词: IGFBP-3AZABreast cancerCell survival
原始语种摘要: Abstract(#br)Breast cancer progression is associated with loss of estrogen receptor (ER-α), often due to epigenetic silencing. IGFBP genes have consistently been identified among the most common to be aberrantly methylated in tumours. To understand the impact of losing IGFBP-3 tumour expression via DNA methylation, we treated four breast cancer cell lines (MCF-7, T47D, Hs578T and MDA-MB-231) with a DNA methyltransferase inhibitor, 5-Aza-2′-deoxycytidine (AZA) to determine IGFBP-3's role in the effects of AZA on total cell number and survival relative to changes in the ER. AZA induced cell growth inhibition, death and a reduction in the formation of colonies, despite increasing ER-α expression in ER-negative cells but reducing ER-α in ER-positive cells. Regardless of the differential...
全文获取路径: Elsevier  (合作)
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影响因子:3.557 (2012)

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关键词翻译
关键词翻译
  • deoxycytidine 脱氧胞啶
  • AZA ALITALIA-LINEE AEREE ITALIANE
  • breast 胸部
  • tumorigenic 致瘤的
  • cells 麻风细胞
  • cancer 癌症
  • survival 生存
  • growth 生长
  • epigenetic 后成的
  • consistently 一贯地