Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model
作者: Asma LamineMyriam LétourneauNgoc Duc DoanJulie MaucotelAlain CouvineauHubert VaudryDavid ChatenetDavid VaudryAlain Fournier
作者单位: 1INRS – Institut Armand-Frappier, 531 boul. des Prairies, Laval, QC H7V 1B7, Canada
2Laboratoire International Associé Samuel de Champlain, Université de Rouen, France
3INSERM-U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, IRIB, Université de Rouen, 76821 Mont-Saint-Aignan, France
4INSERM U1149/Inflammation Research Center (CRI), Université Paris-Diderot, Faculté de Médecine Site Bichat, 16, rue H. Huchard, 75018 Paris, France
刊名: Neuropharmacology, 2016, Vol.108 , pp.440-450
来源数据库: Elsevier Journal
DOI: 10.1016/j.neuropharm.2015.05.014
关键词: NeurodegenerationNeurodegenerative disordersPACAPDopaminergic neuron survivalSH-SY5Y neuroblastoma cell survivalVasodilation
英文摘要: Abstract(#br)Parkinson's disease (PD) is characterized by a steady loss of dopamine neurons through apoptotic, inflammatory and oxidative stress processes. In that line of view, the pituitary adenylate cyclase-activating polypeptide (PACAP), with its ability to cross the blood–brain barrier and its anti-apoptotic, anti-inflammatory and anti-oxidative properties, has proven to offer potent neuroprotection in various PD models. Nonetheless, its peripheral actions, paired with low metabolic stability, hampered its clinical use. We have developed Ac-[Phe( p I) 6 , Nle 17 ]PACAP(1-27) as an improved PACAP-derived neuroprotective compound. In vitro , this analog stimulated cAMP production, maintained mitochondrial potential and protected SH-SY5Y neuroblastoma cells from...
全文获取路径: Elsevier  (合作)
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影响因子:4.114 (2012)

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关键词翻译
关键词翻译
  • displaying 显示器
  • pituitary 垂体的
  • adenylate 腙甙酸盐
  • activating 激活
  • cyclase 环化酶
  • potent 强大的
  • reduced 减缩的
  • polypeptide 多肽
  • disease 
  • synthetic 合成的