Purinergic contribution to amyotrophic lateral sclerosis
作者: Cinzia VolontéSavina ApolloniChiara ParisiSusanna Amadio
作者单位: 1Institute of Cell Biology and Neurobiology, CNR, Rome, Italy
2Fondazione Santa Lucia, IRCCS, Rome, Italy
刊名: Neuropharmacology, 2016, Vol.104 , pp.180-193
来源数据库: Elsevier Journal
DOI: 10.1016/j.neuropharm.2015.10.026
关键词: CD39M1/M2 microgliaMotoneuronOligodendrocyteP2X7P2Y12
原始语种摘要: Abstract(#br)By signalling through purinergic receptors classified as ionotropic P2X (for ATP) and metabotropic P1 (for adenosine) and P2Y (mainly for ADP, UDP, UTP, ATP), the extracellular nucleotides and their metabolic derivatives originated by extracellular activity of several different ectonucleotidases, are involved in the functioning of the nervous system. Here they exert a central role during physiological processes, but also in the precarious balance between beneficial and noxious events. Indeed, in recent years, the dysregulation of extracellular purinergic homeostasis has been correlated to well-characterized acute and chronic neurodegenerative and neuroinflammatory diseases. Among these, we focus our attention on purinergic signalling occurring in amyotrophic lateral sclerosis...
全文获取路径: Elsevier  (合作)
影响因子:4.114 (2012)

  • amyotrophic 肌肉萎缩的
  • sclerosis 硬化
  • lateral 侧面的
  • contribution 贡献