Pharmacokinetic Properties and Tolerability of Rotigotine Transdermal Patch After Repeated-Dose Application in Healthy Korean Volunteers
作者: Bo-Hyung KimKyung-Sang YuIn-Jin JangKyoung Soo LimJung-Ryul KimJan-Peer ElshoffJens-Otto AndreasMarina BraunWilli Cawello
作者单位: 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea
2Department of Clinical Pharmacology and Therapeutics, Kyung Hee University College of Medicine and Hospital, Seoul, Republic of Korea
3Department of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center, Seongnam, Republic of Korea
4Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Seoul, Republic of Korea
5UCB Pharma, Monheim and Rhein, Germany
刊名: Clinical Therapeutics, 2015, Vol.37 (4), pp.902-912
来源数据库: Elsevier Journal
DOI: 10.1016/j.clinthera.2015.01.013
关键词: pharmacokineticsrotigotinesafetytolerability
原始语种摘要: Abstract(#br)Purpose(#br)Rotigotine, a nonergolinic dopamine receptor agonist, is a once-daily transdermal patch developed for the treatment of Parkinson’s disease and restless legs syndrome. The objective of the present study was to determine the pharmacokinetic characteristics and tolerability of rotigotine transdermal patch after repeated-dose application in healthy male and female Korean subjects.(#br)Methods(#br)In this randomized, double-blind, placebo-controlled, repeated-dose study, subjects were randomly assigned to receive either rotigotine or placebo (ratio, 20 rotigotine to 4 placebo, per sex). Rotigotine patches were applied once daily at a dose of 2 mg/24 h on days 1 to 3, followed by 4 mg/24 h on days 4 to 6. Serial blood and urine samples were collected on days 1 to 9 for...
全文获取路径: Elsevier  (合作)
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来源刊物:
影响因子:2.23 (2012)

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关键词翻译
关键词翻译
  • unconjugated 非结合的
  • concentrations 浓聚物
  • transdermal 穿过表皮的
  • tolerability 可容许性
  • laboratory 实验室
  • placebo 无效对照药
  • orthostatic 体位性的
  • healthy 健康的
  • state 状态
  • determination 测定