A novel model to characterize postnatal exposure to lipophilic environmental toxicants and application in the study of hexachlorobenzene and infant growth
作者: Hein StigumNina IszattAnuschka PolderSiddhartha MandalMerete Eggesbø
作者单位: 1Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, NO-0403 Oslo, Norway
2Norwegian School of Veterinary Science, Oslo, Norway
3National Veterinary Institute, Oslo, Norway
刊名: Environment International, 2015, Vol.85 , pp.156-162
来源数据库: Elsevier Journal
DOI: 10.1016/j.envint.2015.08.011
关键词: Postnatal exposureHCBModelingInfant growthLinear mixed model
原始语种摘要: Abstract(#br)Background(#br)Infants are exposed to persistent environmental contaminants through breast milk, yet studies assessing the health effects of postnatal exposure are lacking. Existing postnatal exposure assessment is either too simple (lactation exposure model, LEM) or requires complex physiologically-based pharmacokinetic (PBPK) models.(#br)Objectives(#br)We present equations for postnatal exposure calculations. We applied these equations to study the effect of hexachlorobenzene (HCB) on infant growth in the two first years of life.(#br)Methods(#br)HCB was measured in breast milk samples in 449 mother-child pairs participating in the Norwegian birth cohort study HUMIS. We used these concentrations, mother's weight, height and age, together with child's weight at 8 age points,...
全文获取路径: Elsevier  (合作)
影响因子:6.248 (2012)

  • postnatal 出生后的
  • exposure 暴露
  • infant 幼儿
  • lipophilic 亲油性
  • growth 生长
  • characterize 成为...的特性
  • novel 长篇小说
  • effect 效应
  • concentrations 浓聚物
  • month