Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins
作者: Nicholas R. BerlonRobert QiBatu K. Sharma-KuinkelHwang-Soo JooLawrence P. ParkDennis GeorgeJoshua T. ThadenJulia A. MessinaStacey A. MaskarinecManica Mueller-PremruEugene AthanPierre TattevinJuan M. PericasChristopher W. WoodsMichael OttoVance G. Fowler
作者单位: 1Duke U Med Center, NC, USA
2National Institutes of Health, MD, USA
3University of Ljubljana, Ljubljana, Slovenia
4Barwon Health, Deakin University, VIC, Australia
5Pontchaillou University, Pontchaillou, France
6Hospital Clinic – IDIBAPS. Univ. Barcelona, Spain
刊名: Journal of Infection, 2015, Vol.71 (4), pp.447-457
来源数据库: Elsevier Journal
DOI: 10.1016/j.jinf.2015.06.005
关键词: Phenol soluble modulinMRSASkin and soft tissue infectionPneumoniaEndocarditis
英文摘要: Summary(#br)Background(#br)Phenol-soluble modulins (PSMs) are amphipathic, pro-inflammatory proteins secreted by most Staphylococcus aureus isolates. This study tested the hypothesis that in vitro PSM production levels are associated with specific clinical phenotypes.(#br)Methods(#br)177 methicillin-resistant S. aureus (MRSA) isolates from infective endocarditis (IE), skin and soft tissue infection (SSTI), and hospital-acquired/ventilator-associated pneumonia (HAP) were matched by geographic origin, then genotyped using spa -typing. In vitro PSM production was measured by high performance liquid chromatography/mass spectrometry. Statistical analysis was performed using Chi-squared or Kruskal–Wallis tests as appropriate.(#br)Results(#br)Spa type 1 was significantly more common in SSTI...
全文获取路径: Elsevier  (合作)
影响因子:4.073 (2012)

  • increased 增加
  • tissue 组织
  • vitro 体外
  • soluble 可溶的
  • isolates 单离体
  • production 生产
  • phenol