TRPC6 gene variants and neuropsychiatric lupus
作者: Giuseppe A. RamirezChiara LanzaniEnrica P. BozzoloLorena CitterioLaura ZagatoNunzia CasamassimaValentina CantiMaria Grazia SabbadiniPatrizia Rovere-QueriniPaolo ManuntaAngelo A. Manfredi
作者单位: 1Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan, Italy
2Università Vita-Salute San Raffaele, Milan, Italy
3Unit of Nephrology, IRCCS Ospedale San Raffaele, Milan, Italy
刊名: Journal of Neuroimmunology, 2015, Vol.288 , pp.21-24
来源数据库: Elsevier Journal
DOI: 10.1016/j.jneuroim.2015.08.015
关键词: LupusGeneticsTRPC6Neuropsychiatric involvement
原始语种摘要: Abstract(#br)Neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) influence patients' quality of life and their survival. Little is known about the pathophysiological bases of NPSLE and accordingly there are no specific therapeutic agents to be employed in this setting. Genetic research in systemic lupus erythematosus (SLE) is rapidly evolving as a tool to find clues about the pathogenic determinants of the disease and of its manifestations. Here, we describe the association of a single nucleotide polymorphic variant of the transient receptor potential cation channel, subfamily C, member 6 (TRPC6) gene with protection from the development of NPSLE in a cohort of 106 patients with SLE. TRPC6 is involved in the regulation of N-methyl- d -aspartate (NMDA) receptor...
全文获取路径: Elsevier  (合作)
影响因子:3.033 (2012)

  • 核苷酸 生存
  • lupus 豺狼座
  • SLE 全身性红斑狼疮
  • systemic 系统的
  • Lupus 豺狼星座
  • receptor 接受体
  • potential 
  • therapeutic 治疗的
  • aspartate 天冬氨酸盐
  • survival 生存
  • nucleotide 生存