Synergistic antitumor effects of radiation and proteasome inhibitor treatment in pancreatic cancer through the induction of autophagy and the downregulation of TRAF6
作者: Hui-Wen ChiuShu-Wen LinLi-Ching LinYung-Ho HsuYuh-Feng LinSheng-Yow HoYuan-Hua WuYing-Jan Wang
作者单位: 1Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
2Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan
3Department of Environmental and Occupational Health, National Cheng Kung University, Tainan, Taiwan
4Department of Radiation Oncology, Chi Mei Medical Center, Tainan, Taiwan
5School of Medicine, Taipei Medical University, Taipei, Taiwan
6Department of Radiation Oncology, Chi Mei Medical Center, Liouying, Tainan, Taiwan
7Chang Jung Christian University, Tainan, Taiwan
8Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
9Department of Biomedical Informatics, Asia University, Taichung, Taiwan
10Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan
刊名: Cancer Letters, 2015, Vol.365 (2), pp.229-239
来源数据库: Elsevier Journal
DOI: 10.1016/j.canlet.2015.05.025
关键词: RadiationProteasome inhibitorAutophagyEndoplasmic reticulum stressPancreatic cancer
原始语种摘要: Abstract(#br)Ninety percent of human pancreatic cancer is characterized by activating K-RAS mutations. TRAF6 is an oncogene that plays a vital role in K-RAS-mediated oncogenesis. We investigated the synergistic effect of combining ionizing radiation (IR) and proteasome inhibitor (MG132). Furthermore, following combined treatment with IR and MG132, we analyzed the expression of TRAF6 and the mechanism of human pancreatic cancer cell death in vitro and in an orthotopic pancreatic cancer mouse model. The combined treatment groups displayed synergistic cell killing effects and induced endoplasmic reticulum stress in human pancreatic cancer cells. The combined treatment groups were characterized by enhanced cytotoxicity, which resulted from increased autophagy induction through the inhibition...
全文获取路径: Elsevier  (合作)
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影响因子:4.258 (2012)

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关键词翻译
关键词翻译
  • pancreatic 胰的
  • autophagy 自体消瘦
  • antitumor 抗癌的
  • radiation 辐射
  • cancer 癌症
  • inhibitor 抑制剂
  • combined 组合
  • treatment 处理
  • induction 诱发
  • oncogenesis 肿瘤发生