Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans
作者: Lei LiGiulia M. PiloXiaolei LiAntonio CiglianoGavinella LatteLi CheChristy JosephMarta MelaChunmei WangLijie JiangSilvia RibbackMaria M. SimileRosa M. PascaleFrank DombrowskiMatthias EvertClay F. SemenkovichXin ChenDiego F. Calvisi
作者单位: 1School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA, USA
3Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy
4Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, China
5Institut für Pathologie, Universitätsmedizin Greifswald, Greifswald, Germany
6Division of Endocrinology, Metabolism & Lipid Research, Washington University School of Medicine, St. Louis, MO, USA
刊名: Journal of Hepatology, 2016, Vol.64 (2), pp.333-341
来源数据库: Elsevier Journal
DOI: 10.1016/j.jhep.2015.10.004
关键词: Hepatocellular carcinomaLipogenesisFatty acid synthaseAKTRictor
英文摘要: Background & Aims(#br)Cumulating evidence underlines the crucial role of aberrant lipogenesis in human hepatocellular carcinoma (HCC). Here, we investigated the oncogenic potential of fatty acid synthase (FASN), the master regulator of de novo lipogenesis, in the mouse liver.(#br)Methods(#br)FASN was overexpressed in the mouse liver, either alone or in combination with activated N-Ras, c-Met, or SCD1, via hydrodynamic injection. Activated AKT was overexpressed via hydrodynamic injection in livers of conditional FASN or Rictor knockout mice. FASN was suppressed in human hepatoma cell lines via specific small interfering RNA.(#br)Results(#br)Overexpression of FASN , either alone or in combination with other genes associated with hepatocarcinogenesis, did not induce histological liver...
全文获取路径: Elsevier  (合作)
影响因子:9.858 (2012)

  • synthase 合酶
  • carcinoma 癌症
  • driven 从动的
  • fatty 脂肪的