Dentin and pulp sense cold stimulus
作者: Masayuki TokudaShoko TatsuyamaMari FujisawaYoko Morimoto-YamashitaYoshiko KawakamiYoshiyuki ShibukawaMistuso Torii
作者单位: 1Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan
2Department of Physiology, Tokyo Dental College, Tokyo 101-0061, Japan
刊名: Medical Hypotheses, 2015, Vol.84 (5), pp.442-444
来源数据库: Elsevier Journal
DOI: 10.1016/j.mehy.2015.01.039
英文摘要: Abstract(#br)Dentin hypersensitivity is a common symptom, and recent convergent evidences have reported transient receptor potential (TRP) channels in odontoblasts act as mechanical and thermal molecular sensor, which detect stimulation applied on the exposed dentin surface, to drive multiple odontoblastic cellular functions, such as sensory transduction and/or dentin formation. In the present study, we confirmed expression of TRP melastatin subfamily member-8 (TRPM8) channels in primary cultured cells derived from human dental pulp cells (HPCs) and mouse odontoblast-lineage cells (OLCs) as well as in dentin matrix protein-1 (DMP-1) and dentin sialoprotein (DSP) positive acutely isolated rat odontoblasts from dental pulp tissue slice culture by immunohistochemical analyses. In addition,...
全文获取路径: Elsevier  (合作)
影响因子:1.054 (2012)

  • sense 方向
  • stimulus 刺激