Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Tunisian Arab subjects
作者: Amira TurkiGhadeer S. Al-ZabenNabil MtiraouiHela MarmmuochTouhami MahjoubWassim Y. Almawi
作者单位: 1Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia
2Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain
3Department of Endocrinology, CHU Fattouma Bourguiba, Monastir, Tunisia
刊名: Gene, 2013, Vol.513 (2), pp.244-248
来源数据库: Elsevier Journal
DOI: 10.1016/j.gene.2012.10.086
关键词: DiabetesGenome wide associationReplicationTCF7L2
原始语种摘要: Abstract(#br)Genome-wide association studies validated transcription factor 7-like 2 ( TCF7L2 ) gene as confirmed type 2 diabetes (T2DM) susceptibility locus, and an ethnic contribution of TCF7L2 variants to T2DM risk was indicated. The aim of this study was to replicate in a Tunisian Arab population identified associations of common TCF7L2 variants with T2DM. We tested the association of TCF7L2 variants: rs4506565, rs7903146, rs12243326, and rs12255372, with T2DM in 900 Tunisian patients and 875 control subjects. TCF7L2 genotyping was done by allelic discrimination/real-time PCR method. Minor allele frequencies of rs4506565 ( P =2.4×10 −8 ), rs7903146 ( P =...
全文获取路径: Elsevier  (合作)
影响因子:2.196 (2012)

  • TCF Trim Centering and Feel
  • factor 因素
  • associated 相关的
  • diabetes 糖尿病
  • common 普通
  • locus 轨迹
  • ethnic 种族
  • candidate 选择物
  • association 联合
  • strongly 强烈地