A slow-release system of bacterial cellulose gel and nanoparticles for hydrophobic active ingredients
作者: Yukari NumataLeticia MazzarinoRedouane Borsali
作者单位: 1Centre de Recherches sur les Macromoléculés Végétales (CERMAV, UPR-CNRS 5301), Université Grenoble Alpes, BP 53, F-38041 Grenoble Cedex 9, France
2Department of Materials Chemistry, Asahikawa National College of Technology, Asahikawa 071-8142, Japan
3Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis 88040-900, Brazil
刊名: International Journal of Pharmaceutics, 2015, Vol.486 (1-2), pp.217-225
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijpharm.2015.03.068
关键词: Bacterial cellulose gelNanoparticlesBlock copolymerBiocompatibilityDrug delivery systemRetinol
原始语种摘要: Abstract(#br)A combination of bacterial cellulose (BC) gel and amphiphilic block copolymer nanoparticles was investigated as a drug delivery system (DDS) for hydrophobic active ingredients. Poly(ethylene oxide)- b -poly(caprolactone) (PEO- b -PCL) and retinol were used as the block copolymer and hydrophobic active ingredient, respectively. The BC gel was capable of incorporating copolymer nanoparticles and releasing them in an acetic acid–sodium acetate buffer solution (pH 5.2) at 37°C. The percentage of released copolymer reached a maximum value of approximately 60% after 6h and remained constant after 24h. The percentage of retinol released from the copolymer-containing BC gel reached a maximum value at 4h....
全文获取路径: Elsevier  (合作)
影响因子:3.458 (2012)

  • hydrophobic 疏水的
  • copolymer 共聚物
  • cellulose 纤维素
  • system 
  • amphiphilic 两亲的
  • caprolactone 已内酯
  • bacterial 细菌的
  • maximum 最大值
  • release 释放
  • retinol 瑞叮醇