In vitro and in vivo anti-inflammatory activity of Phyllanthus acidus methanolic extract
作者: Muhammad Jahangir HossenSung Ho JeonSeung Cheol KimJi Hye KimDeok JeongNak Yoon SungSungjae YangKwang-Soo BaekJun Ho KimDeok Hyo YoonWon O. SongKee Dong YoonSang-Ho ChoSukchan LeeJong-Hoon KimJae Youl Cho
作者单位: 1Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea
2Department of Animal Science, Patuakhali Science and Technology University, Bangladesh
3Department of Life Science Hallym University, Chuncheon 200-702, Republic of Korea
4Division of Gynecologic Oncology Department of Obstetrics and Gynecology, Ewha Womans University Mokdong Hospital College of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea
5Department of Biochemistry, Kangwon National University, Chuncheon 220-700, Republic of Korea
6Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA
7College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Republic of Korea
8Department of Veterinary Physiology, College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Jeonju 561-756, Republic of Korea
刊名: Journal of Ethnopharmacology, 2015, Vol.168 , pp.217-228
来源数据库: Elsevier Journal
DOI: 10.1016/j.jep.2015.03.043
关键词: Phyllanthus acidusPhyllanthaceaeanti-inflammatory effectproteinTyrosine kinaseprostaglandin E 2Nuclear factor-κB
原始语种摘要: Abstract(#br)Ethnopharmacological relevance(#br)Phyllanthus acidus (L.) Skeels (Phyllanthaceae) has traditionally been used to treat gastric trouble, rheumatism, bronchitis, asthma, respiratory disorders, and hepatitis. Despite this widespread use, the pharmacological activities of this plant and their molecular mechanisms are poorly understood. Therefore, we evaluated the immunopharmacological activities of the methanolic extract of the aerial parts of this plant (Pa-ME) and validated its pharmacological targets.(#br)Materials and methods(#br)Lipopolysaccharide (LPS)-treated macrophages, an HCl/EtOH-induced gastritis model, and an acetic acid-injected capillary permeability mouse model were employed to evaluate the anti-inflammatory activity of Pa-ME. Potentially active anti-inflammatory...
全文获取路径: Elsevier  (合作)
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影响因子:2.755 (2012)

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关键词翻译
关键词翻译
  • inflammatory 激怒的
  • extract 提取
  • activity 活度
  • induced 感应的
  • suppressed 被抑制的
  • gastric 胃的
  • prostaglandin 前列腺素
  • enzymatic 酶催的
  • luciferase 荧光素酶
  • kaempferol 7三羟黄酮醇