Thiophene and benzodioxole appended thiazolyl-pyrazoline compounds: Microwave assisted synthesis, antimicrobial and molecular docking studies
作者: S. Shahavar SulthanaS. Arul AntonyC. BalachandranS. Syed Shafi
作者单位: 1PG & Research Department of Chemistry, Presidency College, Chennai 600 005, India
2Division of Microbiology and Cancer Biology, Entomology Research Institute, Loyola College, Chennai 600034, India
3Department of Chemistry, Thiruvalluvar University, Serkadu, Vellore 632 115, India
刊名: Bioorganic & Medicinal Chemistry Letters, 2015, Vol.25 (14), pp.2753-2757
来源数据库: Elsevier Journal
DOI: 10.1016/j.bmcl.2015.05.033
关键词: ThiazolePyrazolineAntimicrobialMolecular docking
原始语种摘要: Abstract(#br)A novel series of thiophene and benzodioxole appended thiazolyl-pyrazoline derivatives have been designed, synthesized and evaluated against different bacteria and fungi. The antimicrobial activity of the synthesized compounds were screened using MIC method and were proved synthesized compounds 7o , 7r and 7t to show good antimicrobial activity against bacteria and fungi. In silico molecular docking studies revealed that all the synthesized molecules showed good binding energy toward the target receptor DNA topoisomerase IV, ranging from −10.42 to −11.66kcal/mol.
全文获取路径: Elsevier  (合作)
影响因子:2.338 (2012)

  • docking 靠泊
  • pyrazoline 吡唑啉
  • antimicrobial 杀菌剂
  • thiazolyl 噻唑基
  • assisted 辅助的
  • synthesis 合成
  • molecular 分子的
  • compounds 化合物