Renal Morphology, Clinical Findings, and Progression Rate in Mesoamerican Nephropathy
作者: Julia WijkströmMarvin González QuirozMario HernandezZulma TrujilloKjell HultenbyAnneli RingMagnus SöderbergAurora AragónCarl-Gustaf ElinderAnnika Wernerson
作者单位: 1Division of Renal Medicine, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
2Research Center on Health, Work and Environment, National Autonomous University of Nicaragua at León, León, Nicaragua
3Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom
4Department of Pediatrics, National Autonomous University of Nicaragua at León, León, Nicaragua
5Servicio de Nefrología, Hospital Nacional Rosales, San Salvador, El Salvador
6Division of CRC, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
7Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden
8Drug Safety and Metabolism, AstraZeneca, Mölndal, Sweden
9Clinical Pathology and Cytology, Karolinska University Hospital Huddinge, Stockholm, Sweden
刊名: American Journal of Kidney Diseases, 2016
来源数据库: Elsevier Journal
DOI: 10.1053/j.ajkd.2016.10.036
关键词: Mesoamerican nephropathy (MeN)chronic kidney disease (CKD)renal pathologyrenal morphologykidney biopsyCentral Americaheat stressdehydrationsugarcaneenvironmental exposureCKD of unknown etiology (CKDu)endemic nephropathydisease progressionNicaraguaEl Salvador
英文摘要: Background(#br)Mesoamerican nephropathy (MeN) is a chronic kidney disease affecting rural inhabitants in Central America. We have previously described the renal morphology in 8 patients from El Salvador. To confirm the renal pathology, we have studied kidney biopsies from patients with MeN in Nicaragua. Follow-up urine and blood samples from both biopsy studies were collected to investigate the natural history.(#br)Study Design(#br)Case series.(#br)Settings & Participants(#br)In the kidney biopsy study, 19 male sugarcane workers in Nicaragua with suspected MeN were investigated with questionnaires, kidney biopsies, and blood and urine analysis. Inclusion criteria were age 20 to 65 years and plasma creatinine level of 1.13 to 2.49mg/dL or estimated glomerular filtration...
全文获取路径: Elsevier  (合作)
影响因子:5.294 (2012)