Glucose tolerance and free fatty acid metabolism in adults with variations in TCF7L2 rs7903146
作者: Jin LuRon T. VargheseLianzhen ZhouAdrian VellaMichael D. Jensen
作者单位: 1Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai, PR China
2Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, MN
刊名: Metabolism, 2017, Vol.68 , pp.55-63
来源数据库: Elsevier Journal
DOI: 10.1016/j.metabol.2016.11.018
关键词: PrediabetesInsulin secretionInsulin actionFatty acidsFree fatty acids
原始语种摘要: Abstract(#br)Objective(#br)TCF7L2 variant rs7903146 is associated with increased risk for type 2 diabetes. We investigated the effect of TCF7L2 variant rs7903146 and glucose tolerance on free fatty acid (FFA) metabolism.(#br)Research Design and Methods(#br)We recruited 120 individuals, half homozygous for the major CC allele and half homozygous for the minor TT allele at rs7903146; each underwent a 2-h, 75g oral glucose tolerance test (OGTT). Plasma glucose, insulin and free fatty acid concentrations were measured on blood collected before and during the OGTT.(#br)Results(#br)Total FFA concentrations and percent FA species during OGTT were not different in CC and TT carriers when males and females were considered together. However, monounsaturated fatty acid (MUFA)...
全文获取路径: Elsevier  (合作)
影响因子:3.096 (2012)

  • tolerance 耐性
  • fatty 脂肪的
  • secretion 分泌
  • metabolism 代谢
  • TCF Trim Centering and Feel
  • action 行为