Anti-tumor activity of dual inhibition of phosphatidylinositol 3-kinase and MDM2 against clear cell ovarian carcinoma
作者: Chinami MakiiYuji IkedaKatsutoshi OdaYuriko UeharaAkira NishijimaTakahiro KosoYoshiko KawataTomoko KashiyamaAki MiyasakaKenbun SoneMichihiro TanikawaTetsushi TsurugaMayuyo Mori-UchinoKazunori NagasakaYoko MatsumotoOsamu Wada-HiraikeKei KawanaKosei HasegawaKeiichi FujiwaraHiroyuki AburataniYutaka OsugaTomoyuki Fujii
作者单位: 1Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Japan
2Current address; Department of Obstetrics and Gynecology, Nihon University, Tokyo, Japan
3Division of Genome Science, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
4Department of Obstetrics and Gynecology, Nihon University, Tokyo, Japan
5Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Saitama, Japan
刊名: Gynecologic Oncology, 2019, Vol.155 (2), pp.331-339
来源数据库: Elsevier Journal
DOI: 10.1016/j.ygyno.2019.08.028
关键词: Clear cell ovarian carcinomaPhosphatidylinositol-45-bisphosphate 3-kinase (PI3K) pathwayMDM2PrognosisMolecular targeted therapy
英文摘要: Abstract(#br)Introduction(#br)PI3K pathway signaling has received attention as a molecular target in clear cell ovarian carcinoma (CCOC). MDM2 is one of the AKT effectors in the PI3K pathway, which binds to and degrades p53. In this study, we aimed to clarify the prognostic significance of PIK3CA and MDM2 expression, and potential therapeutic effect of a dual inhibition of the PI3K pathway and MDM2.(#br)Materials and methods(#br)cDNA expression was evaluated by using microarray data using 75 samples of CCOC. DS-7423 (dual inhibitor of pan-PI3K and mTOR) and RG7112 (MDM2 inhibitor) were used on CCOC cell lines to evaluate cell proliferation, expression level of MDM2 related proteins, and apoptosis by MTT assay, western blotting, and flow cytometry. DS-7423 (3 mg/kg) and/or RG7112 (50...
全文获取路径: Elsevier  (合作)
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影响因子:3.929 (2012)

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关键词翻译
关键词翻译
  • ovarian 卵巢的
  • carcinoma 癌症
  • kinase 激酶
  • targeted 对准目标的
  • tumor 肿胀
  • pathway 轨道
  • against 反对
  • inhibition 抑制
  • activity 活度
  • clear 昧的