Distribution of keratins in normal endothelial cells and a spectrum of vascular tumors: Implications in tumor diagnosis
作者: Markku MiettinenJohn F. Fetsch
作者单位: 1From the Armed Forces Institute of Pathology, Department of Soft Tissue Pathology, Washington, DC.
刊名: Human Pathology, 2000, Vol.31 (9), pp.1062-1067
来源数据库: Elsevier Journal
DOI: 10.1053/hupa.2000.9843
原始语种摘要: Abstract(#br)Vascular endothelial cells are specialized mesenchyme-derived epithelial-like lining cells which are the essential participants in benign and malignant vascular tumors. Although endothelia in lower animals often express keratins (K), human endothelia are generally K negative and vimentin-positive. However, K expression has been noted in some endothelia and in some epithelioid vascular tumors. In this study, we systematically examined normal human vascular endothelia and a spectrum of human vascular tumors ( n = minimum of 137 tumors with each marker) for simple epithelial keratin polypeptides of the Moll catalogue (K7, K8, K18, and K19). Selected vascular tumors were also evaluated with antibodies to K14 and the monoclonal antibody 34βE12 that recognizes several keratins of...
全文获取路径: Elsevier  (合作)
影响因子:2.843 (2012)

  • vascular 维管的
  • endothelial 内皮的
  • cells 麻风细胞
  • occasionally 有时
  • epithelioid 上皮样的
  • normal 法线
  • mesenchyme 间质
  • epithelial 上皮的
  • expression 表示
  • antibody 抗体