Expression and function of the stromal cell-derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) in the swine ovarian follicle
作者: G. BasiniL. RagionieriS. BussolatiR. Di LecceA. CacchioliM. DettinA.M. CantoniS. GrolliO. La BellaA. ZamunerF. Grasselli
作者单位: 1Dipartimento di Scienze Medico-Veterinarie, Università di Parma, Via del Taglio 10, 43126 Parma, Italy
2Dipartimento di Ingegneria Industriale, Università di Padova, Via Marzolo, 9, 35131 Padova, Italy
刊名: Domestic Animal Endocrinology, 2020, Vol.71
来源数据库: Elsevier Journal
DOI: 10.1016/j.domaniend.2019.106404
关键词: OvaryGranulosa cellsSteroidogenesisCell proliferationFree radicalsAngiogenesis
原始语种摘要: Abstract(#br)The most characterized stromal cell-derived factor-1 (SDF-1) variants are the isoform α, which is the predominant one but undergoes rapid proteolysis, and the β isoform, which is more resistant. Through the interaction with a specific chemokine receptor called CXCR4, SDF-1 is able to regulate different physiological processes. The aim of this study was to verify the expression and potential functional role of SDF-1 and CXCR4 in the porcine ovary. Firstly, the expression of SDF-1 and its receptor in different ovarian districts was verified for the first time. Thereafter, the effect of SDF-1 β isoform (51–72) fragment on functional parameters, such as proliferation, metabolic activity, redox status, nitric oxide production, and steroidogenic activity, was assessed on granulosa...
全文获取路径: Elsevier  (合作)
影响因子:2.377 (2012)

  • receptor 接受体
  • ovarian 卵巢的
  • follicle 滤泡
  • derived 导生的
  • stromal 基质的
  • factor 因素
  • function 函数
  • swine