The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function
作者: Giuseppe A. RamirezLavinia A. ColettoEnrica P. BozzoloLorena CitterioSimona Delli CarpiniLaura ZagatoPatrizia Rovere-QueriniChiara LanzaniPaolo ManuntaAngelo A. ManfrediClara Sciorati
作者单位: 1Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital & Scientific Institute, Milan, Italy
2Division of Immunology, Transplantation and Infectious Disease, San Raffaele Hospital & Scientific Institute Milan, Italy
3Università Vita-Salute San Raffaele, Milan, Italy
4Unit of Nephrology, IRCCS San Raffaele Hospital & Scientific Institute, Milan, Italy
刊名: Journal of Neuroimmunology, 2018
来源数据库: Elsevier Journal
DOI: 10.1016/j.jneuroim.2018.10.010
关键词: TRPC6Systemic lupus erythematousNeuropsychiatricCalciumApoptosisCytokinesGenetics
英文摘要: Abstract(#br)Patients with systemic lupus erythematosus (SLE) carrying a TT genotype for the rs7925662 single nucleotide polymorphism (SNP) in the transient receptor potential canonical channel 6 (TRPC6) gene are more likely to develop neuropsychiatric manifestations (NPSLE). We functionally characterised the effects of TRPC6 on peripheral blood mononuclear cells from 18 patients with SLE and 8 healthy controls with a known genotype. TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner. Cells from TT patients with NPSLE were more dependent on TRPC6 for the generation of calcium currents.
全文获取路径: Elsevier  (合作)
影响因子:3.033 (2012)

  • lupus 豺狼座
  • erythematous 红斑状的
  • systemic 系统的
  • associated 相关的
  • immune 免疫的
  • polymorphism 多晶形
  • function 函数