Programming changes in GLUT1 mediated the accumulation of AGEs and matrix degradation in the articular cartilage of female adult rats after prenatal caffeine exposure
作者: Li Qing-xianWang Lin-longWang Yi-zhongLiu LiangHan HuiChen Liao-binWang Hui
作者单位: 1Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China
2Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 430071, China
3Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, China
刊名: Pharmacological Research, 2020, Vol.151
来源数据库: Elsevier Journal
DOI: 10.1016/j.phrs.2019.104555
关键词: Prenatal caffeine exposureGlucocorticoidGlucose transporter 1Glucose metabolismArticular cartilageCartilage development
原始语种摘要: Abstract(#br)Osteoarthritis is associated with intrauterine growth retardation (IUGR) and abnormal glucose metabolism. Our laboratory previously reported that prenatal caffeine exposure (PCE) can induce intrauterine maternal glucocorticoid (GC) overexposure in IUGR offspring and increase susceptibility to osteoarthritis after birth. In the present study, we demonstrated the essential role of glucose transporter 1 (GLUT1) programming changes in the increased matrix degradation of articular cartilage and susceptibility to osteoarthritis in female PCE adult offspring. In vivo, we found that PCE decreased the matrix content but did not significantly change the expression of matrix degradation-related genes in the articular cartilage of female fetal rats. The decreased expression of IGF1 and...
全文获取路径: Elsevier  (合作)
影响因子:4.346 (2012)

  • female 女性的
  • degradation 减嚣夷酌
  • expression 表示
  • caffeine 咖啡碱
  • articular 关节的
  • matrix 石基
  • offspring 后代
  • exposure 暴露
  • increased 增加
  • prenatal 产前的