Prevalence and predictive factors of splenic sequestration crisis among 423 pediatric patients with sickle cell disease in Tunisia
作者: Monia Ben KhaledMonia OuederniYosra MankaiSamia RekayaIlhem Ben FrajNawel DhouibRidha KoukiFethi MellouliMohamed Bejaoui
作者单位: 1Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia
2Pediatric Immuno-Hematology Unit, Bone Marrow Transplantation Center Tunis, Tunis, Tunisia
刊名: Blood Cells, Molecules and Diseases, 2020, Vol.80
来源数据库: Elsevier Journal
DOI: 10.1016/j.bcmd.2019.102374
关键词: SpleenSickle cell diseaseChildrenAcute splenic sequestration
原始语种摘要: Abstract(#br)This study was aimed to identify the predictors of splenic sequestration crisis (SSC) among pediatric patients with sickle cell disease (SCD).(#br)This prognosis study was carried out in the pediatric immuno-hematology unit, over 20 years (1998 to 2017), enrolling patients with SCD. The cox model was used in multivariate analysis.(#br)Among 423 patients with SCD (240 S/S phenotype, 128 S/B0, 30 S/B+, 14 S/O arab and 11 S/C), 150(35.4%) had at least one episode of SSC. The average age of patients at the first episode was 48.3 months ± 32.4(2–168). Recurrence of SSC was observed in 117 patients (78%). Spleen size ≥3 cm at baseline was the strongest predictor of SSC occurrence (HR = 7.27, CI: 4.01–13.20, p = 0.05) and recurrence (HR = 6.37, CI: 1,46–27.83, p = 0.01). Pallor...
全文获取路径: Elsevier  (合作)
影响因子:2.259 (2012)

  • sickle 切割器镰刀
  • splenic 脾的
  • sequestration 死骨形成
  • Sickle 轩辕八至十三
  • pediatric 儿科的
  • predictive 预言
  • crisis 危机
  • disease 
  • among 在当中