Gold nanoclusters as contrast agents for fluorescent and X-ray dual-modality imaging
作者: Aili ZhangYu TuSongbing QinYan LiJuying ZhouNa ChenQiang LuBingbo Zhang
作者单位: 1National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China
2School of Radiation Medicine and Protection, Medical College of Soochow University, Soochow University, Suzhou 200072, China
3Department of Radiotherapy, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
4Translational Medicine Research Centre & Central Laboratory, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 200040, China
5The Institute for Advanced Materials & Nano Biomedicine, Tongji University, Shanghai 200092, China
刊名: Journal of Colloid And Interface Science, 2012, Vol.372 (1), pp.239-244
来源数据库: Elsevier Journal
DOI: 10.1016/j.jcis.2012.01.005
关键词: Dual-modality imagingGold nanoclustersFluorescentX-ray imagingContrast agents
英文摘要: Abstract(#br)Multimodal imaging technique is an alternative approach to improve sensitivity of early cancer diagnosis. In this study, highly fluorescent and strong X-ray absorption coefficient gold nanoclusters (Au NCs) are synthesized as dual-modality imaging contrast agents (CAs) for fluorescent and X-ray dual-modality imaging. The experimental results show that the as-prepared Au NCs are well constructed with ultrasmall sizes, reliable fluorescent emission, high computed tomography (CT) value and fine biocompatibility. In vivo imaging results indicate that the obtained Au NCs are capable of fluorescent and X-ray enhanced imaging.
全文获取路径: Elsevier  (合作)
影响因子:3.172 (2012)

  • imaging 图像形成
  • modality 模态
  • fluorescent 萤光的
  • contrast 差异