Unraveling Specific Brain Microstructural Damage in Moyamoya Disease Using Diffusion Magnetic Resonance Imaging and Positron Emission Tomography
作者: Shoko HaraMasaaki HoriRyo UedaShihori HayashiMotoki InajiYoji TanakaTaketoshi MaeharaKenji IshiiShigeki AokiTadashi Nariai
作者单位: 1Department of Neurosurgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
2Department of Radiology, Juntendo University, Bunkyo-ku, Tokyo, Japan
3Team for Neuroimaging Research, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan
刊名: Journal of Stroke and Cerebrovascular Diseases, 2019, Vol.28 (4), pp.1113-1125
来源数据库: Elsevier Journal
DOI: 10.1016/j.jstrokecerebrovasdis.2018.12.038
关键词: Moyamoya diseaseIschemiaCerebral blood flow and metabolismDiffusion MRIMagnetic resonance imagingCognitionCognitive impairment
原始语种摘要: Abstract(#br)Background and Purpose(#br)Chronic ischemia may induce brain microstructural damage and lead to neurocognitive dysfunction in patients with Moyamoya disease (MMD). We applied neurite orientation dispersion and density imaging (NODDI) and 15 O-gas positron emission tomography (PET) to elucidate the specific ischemic brain microstructural damage of MMD in the cortex and the white matter.(#br)Materials and Methods(#br)Thirty-one patients (16-63years old, 9 males) and 20 age- and sex-matched normal controls were enrolled in this study. NODDI evaluates quantitative parameters reflecting neurite and axonal density, network complexity and the interstitial fluid in all participants. Of 31 patients, 12 newly diagnosed patients were evaluated with PET, also. We evaluated correlations...
全文获取路径: Elsevier  (合作)

  • neurite 轴索轴突
  • density 密度
  • impairment 减损
  • interstitial 间隙原子
  • parameters 参数
  • ischemic 福尔克曼氏麻痹
  • PET PagE frame Table
  • imaging 图像形成
  • ischemia 局部贫血
  • brain