Plasma adiponectin is a potential biomarker for organ involvement in male Fabry disease patients
作者: Marina HovakimyanVenkata Ajay Narendra TalabattulaClaudia CozmaChristian BeetzArndt RolfsDeborah Elstein
作者单位: 1CENTOGENE AG, Rostock, Germany
2Medical Faculty, University of Rostock, Rostock, Germany
3Independent consultant, Jerusalem, Israel
刊名: Blood Cells, Molecules and Diseases, 2020, Vol.80
来源数据库: Elsevier Journal
DOI: 10.1016/j.bcmd.2019.102379
关键词: Fabry diseaseCardiovascularRenalAdiponectinLyso-Gb3
英文摘要: Abstract(#br)Fabry disease is an X-linked lysosomal storage disorder caused by pathogenic variants in GLA . It manifests in hemizygous males and in many heterozygous females. Cardiovascular and renal involvement are frequent. Adiponectin is a circulating hormone that has been linked to numerous disease conditions including heart and kidney failure. In the present pilot study, we investigated plasma adiponectin levels in a cohort of 56 individuals with a genetic diagnosis of Fabry disease. Adiponectin levels did not differ between patients and controls. However, in male patients, significantly decreased adiponectin levels were associated with cardiovascular manifestation, while increased levels were associated with renal involvement. Similar trends in female patients did not reach...
全文获取路径: Elsevier  (合作)
影响因子:2.259 (2012)

  • potential 
  • biomarker 生物标志化合物
  • disease 
  • involvement 财政困难
  • organ