Methylation pattern of IFN-γ and IL-10 genes in periodontal tissues
作者: Michelle Beatriz VianaFabiano Pereira CardosoMarina Gonçalves DinizFernando Oliveira CostaJosé Eustáquio da CostaRicardo Santiago GomezPaula Rocha Moreira
作者单位: 1Laboratory of Molecular Biology, Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
2Department of Periodontology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
3Laboratory of Cell-Cell Interactions, Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, CEP 31.270-901, Belo Horizonte, Minas Gerais, Brazil
刊名: Immunobiology, 2011, Vol.216 (8), pp.936-941
来源数据库: Elsevier Journal
DOI: 10.1016/j.imbio.2011.01.006
关键词: CytokinesInflammationMethylationPeriodontitis
原始语种摘要: Abstract(#br)DNA methylation is characterized by the addition of methyl groups in cytosines within CpG islands. Unmethylated CpGs are related to transcriptionally active structure, whereas methylated CpG recruits methyl-binding proteins that promote chromatin compaction. DNA methylation can influence the expression of cytokines and affect the development of periodontal disease.(#br)Objectives(#br)The purpose of the present study was to evaluate the methylation status of the interferon gamma ( IFN-γ ) and interleukin-10 ( IL-10 ) genes in periodontal tissues.(#br)Design(#br)Methylation-specific polymerase chain reaction (MSP) and DNA sequencing analysis were used to verify the DNA methylation status of the IFN-γ and IL-10 genes, respectively, in samples from subjects without periodontitis...
全文获取路径: Elsevier  (合作)
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影响因子:2.814 (2012)

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关键词翻译
关键词翻译
  • periodontal 牙周病学
  • periodontitis 牙周炎
  • methylation 甲基化酌
  • methylated 甲基化了的
  • interleukin 白细胞间介素
  • stained 污损
  • gamma 伽马
  • promote 助长
  • pattern 模型
  • proteins 蛋白质