Behavioral and histological effects of chronic antipsychotic and antidepressant drug treatment in aged rats with focal ischemic brain injury
作者: Chuan-sheng ZhaoKirsi PuurunenTimothy SchallertJuhani SiveniusJukka Jolkkonen
作者单位: 1Department of Neuroscience and Neurology, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland
2Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX, USA
3Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA
4Department of Neurology, University Hospital of Kuopio and Brain Research and Rehabilitation Center Neuron, Kuopio, Finland
刊名: Behavioural Brain Research, 2004, Vol.158 (2), pp.211-220
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbr.2004.09.001
关键词: AgingAntidepressantCerebral ischemiaFunctional recoveryNeuroleptic
原始语种摘要: Abstract(#br)Psychotropic drugs are commonly used in the elderly, including those who may sustain ischemic attacks. Concomitant CNS medication may interfere with functional recovery. The present study evaluated the effect of risperidone, an atypical neuroleptic, and fluoxetine, a selective serotonin reuptake inhibitor, on histological and functional outcome after experimental stroke in aged rats, which might be more vulnerable to brain insults. Aged Wistar rats were treated with risperidone at a dose of 1mg/kg (i.p., once a day), fluoxetine at a dose of 5mg/kg (i.p., once a day), or their combination. Drug treatment was started 7 days before focal cortical photothrombosis (Rose Bengal, 20mg/kg) and continued for 28 days thereafter....
全文获取路径: Elsevier  (合作)
影响因子:3.327 (2012)

  • antipsychotic 抗精神病的
  • antidepressant 抗抑郁药
  • ischemic 福尔克曼氏麻痹
  • neuroleptic 抑制神经的
  • fluoxetine 氟西汀
  • focal 焦点的
  • histological 组织的
  • sensorimotor 感觉运动的
  • impairment 减损
  • atypical 非典型的