TEA Domain Transcription Factor 4 Is the Major Mediator of Yes-Associated Protein Oncogenic Activity in Mouse and Human Hepatoblastoma
作者: Jie ZhangPin LiuJunyan TaoPan WangYi ZhangXinhua SongLi ChePavel SumazinSilvia RibbackAndras KissZsuzsa SchaffAntonio CiglianoFrank DombrowskiCarla CossuRosa M. PascaleDiego F. CalvisiSatdarshan P. MongaXin Chen
作者单位: 1Department of Thoracic Oncology II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, People's Republic of China
2Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, San Francisco, California
3Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China
4Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania
5Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, People's Republic of China
6Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas
7Institute of Pathology, University of Greifswald, Greifswald, Germany
8Second Department of Pathology, Semmelweis University, Budapest, Hungary
9National Institute of Gastroenterology S. de Bellis, Research Hospital, Castellana Gro
刊名: The American Journal of Pathology, 2019, Vol.189 (5), pp.1077-1090
来源数据库: Elsevier Journal
DOI: 10.1016/j.ajpath.2019.01.016
英文摘要: Hepatoblastoma (HB) is the most common type of pediatric liver cancer. Activation of yes-associated protein (YAP) has been implicated in HB molecular pathogenesis. The transcriptional co-activator Yap regulates downstream gene expression through interaction with the TEA domain (TEAD) proteins. Nonetheless, YAP also displays functions that are independent of its transcriptional activity. The underlying molecular mechanisms by which Yap promotes HB development remain elusive. In the current study, we demonstrated that blocking TEAD function via the dominant-negative form of TEAD2 abolishes Yap-driven HB formation in mice and restrains human HB growth in vitro . When TEAD2 DNA-binding domain was fused with virus protein 16 transcriptional activation domain, it synergized with activated...
全文获取路径: Elsevier  (合作)
影响因子:4.522 (2012)

  • Mediator 梅日迪亚托牌手表
  • Domain 区域